Comparison of SANTYL vs. Hydrogel in Debridement of Inflamed Diabetic Foot Ulcers: Study Start Date : July 2010: Actual Primary Completion Date : Contraindications or known hypersensitivity to the test articles or their components. Contraindications. Patient was educated on contraindication for using Sotalol as follows: Avoid using Sotalol along with any other medications that can cause slowdown of heart rate, such as, Beta blockers and calcium channel blockers. Contraindications or hypersensitivity to the use of the test article or their components (e.g., known hypersensitivity to bacitracin). 5.1 Blood Pressure and Heart Rate Increases . may increase risk of bacteremia. Documentation that other general wound care measures are being taken, as appropriate (e.g., the wound should be cleansed of debris and digested material prior to application of Santyl; whenever infection is present, an appropriate topical antibiotic powder should be 3,4,5,6,7,25,26,27,28,30,31,32 or severely burned areas.8,9,0,12,13,29. Severe perioral burns. Warnings and Precautions : The optimal pH range of collagenase is 6 to 8. the use of Santyl Ointment for the recipients diagnosis. 7.3 Dopaminergic Drugs . Second degree burns generally leave a scar. A wound with a third-degree burn (Bryant & Nix, 2007). Collagenase Santyl Ointment contains 250 units of collagenase enzyme per gram of white petrolatum USP. WebMD provides common contraindications for Santyl topical. Do not use with any silver products as iodine inactivates the silver. What are some practical applications for this drug? 2. Warnings and Precautions : The optimal pH range of collagenase is 6 to 8. Embedded foreign bodies in the burn wound which cannot be immediately removed. What is the prescribers specialty? May be used on low-exuding and non-exuding wounds to assist in autolytic debridement by hydration of necrotic and sloughy tissue and for absorption of exudate. Find out what health conditions may be a health risk when taken with Santyl topical Benefits. After meeting study criteria, participants will be randomly assigned for application of SANTYL or SoloSite to their pressure ulcer for up to 6 weeks. Presence of Eschar. 4 CONTRAINDICATIONS 5 WARNINGS AND PRECAUTIONS . Note: All agents must be prescribed by a provider with a Tennessee Medicaid Provider ID. The information provided in Contraindications of Collagenase Santyl is based on data of another medicine with exactly the same composition as the Collagenase Santyl. 2. Dosage and Administration Dosing: Adult. Silver sulfadiazine (Silvadene) cream Broad spectrum. Solutions of sodium hypochlorite (NaOCl), commonly known as Dakin's solution, have been used in wound care for 100 years. Images. Study Description. Documentation of wound improvement AND 2. Wash hands thoroughly after applying the ointment. Do not use in the presence of a untreated wound infection. Contraindication for Sotalol Use. wet-to-dry dressings, scrubbing, and irrigation. utilizing Micelle Matrix TechnologyTM.This is a concentrated, cell-friendly surfactant to aid in maintaining an optimal moist wound healing environment which promotes autolytic PluroGel is a stable, viscous gel composed of a high concentration of surfactant micelles. 5. The enzyme collagenase is derived from the fermentation by Clostridium histolyticum. CONTRAINDICATIONS MEDIHONEY GEL WITH ACTIVE LEPTOSPERMUM HONEY dressing is not indicated for: - Third degree burns - Patients with a known sensitivity to honey DRESSING CHANGE AND REMOVAL Dressing change frequency will depend on the condition of the patient as well as the level of wound exudate. Known local or systemic hypersensitivity to collagenase. Contraindications Do not use for clients with known sensitivity to collagenase or petrolatum. HYDROLYZED COLLAGEN IN Contraindications: SANTYL is contraindicated in patients who have shown local or systemic hypersensitivity to collagenase. A balanced, moisture-rich environment for the wound bed. SCOPE: application of Santyl; whenever infection is present, an appropriate topical antibiotic powder should be used prior to the application of Santyl) CONTINUATION OF THERAPY: FOR ALL INDICATIONS: 1. Subjects will receive either Santyl ointment or bacitracin ointment to apply to the burn until it heals. Documentation that wound debridement is still incomplete (e.g., continued presence Sterile diluent for reconstitution is provided in the package in a single-use glass vial containing 3 mL of 0.3 mg/mL calcium chloride dihydrate in 0.9% sodium chloride. Santyl ointment is generally used as part of a comprehensive wound care plan that also includes removal of necrotic tissue by mechanical debridement, antibiotic administration for clinically infected wounds, application of wound dressings, and maintenance of a Vancomycin is a prescription drug used to treat a certain intestinal condition ( colitis) that may rarely happen after treatment with antibiotics. Contraindications: SANTYL is contraindicated in patients who have shown local or systemic hypersensitivity to collagenase. First concentrated surfactant topical to soften, loosen and trap/remove necrotic tissue. Hypersensitivity. 90 g tube NDC 50484-010-90. Warnings. Warnings and Precautions: The optimal pH range of collagenase is 6 to 8. Close. Warnings/Precautions General Precautions Enzymatic Inactivation. Contraindications. Subjects will receive either Santyl ointment or bacitracin ointment to apply to the burn until it heals. 1. Codeine is approved to treat pain and cough, and tramadol is approved to treat pain. Call your doctor right away if you have a fever, chills, rapid heartbeats, nausea, vomiting, or diarrhea, or if you feel light-headed or confused. For the Consumer. 2. Contraindications include epithelializing wounds and granulating wounds. Apply daily. 2. What are the advantages, disadvantages, and contraindications of this drug? Higher or lower pH conditions will decrease the enzymes activity and appropriate precautions should be taken. The enzymes in Santyl may increase your risk of infection in the bloodstream. Application is contraindicated in patients who have shown local or systemic hypersensitivity to collagenase. Do not share Santyl with another person, even if they have the same symptoms you have. Subjects enrolled in this study will either use Santyl daily or follow standard care procedures for up to 6 weeks for their diabetic foot wound. Tips. Using them together can result in extreme slowdown of heart rate and can present an emergency. What assessments need to be made prior to administration and how do you evaluate the drug's effectiveness? SANTYL Ointment is a sterile ointment indicated for the debridement of dermal ulcers. Santyl Collagenase An enzymatic debriding agent used for deep partial thickness burns, small full-thickness burns or wounds with a fibrinous exudate. USES: This medication is also known as trolamine polypeptide oleate.It is used to remove earwax buildup before an ear examination, treatment, or hearing test. Cautions. However, 3 days later, the patient presented to the ER for abdominal wound opening and incisional tenderness. Does the recipient have documentation of an initial evaluation performed by a burn or wound care specialist High sugar levels (87%) in TheraHoney result in osmotic pressure that helps promote autolytic debridement of necrotic tissue, a moist wound healing environment and helps rapidly reduce wound odor. Collagenase Santyl Ointment is contraindicated in patients who have shown local or systemic hypersensitivity to collagenase. Collagenase SANTYL* Ointment is indicated for debriding chronic dermal ulcers and severely burned areas. It may help wounds heal faster. Contraindications: SANTYL is contraindicated in patients who have shown local or systemic hypersensitivity to collagenase. Higher or lower pH conditions will decrease the enzymes activity and appropriate precautions should be taken. CONTRAINDICATIONS. If experienced, these tend to have a Less Severe expression i. erythema or redness of skin or mucous membrane. Contraindications Collagenase SANTYL* is contraindicated in patients who have shown local or systemic hypersensitivity to collagenase. Santyl contraindications. Store in refrigerator at 28 C (3646 F), may store at room temperature, 1530 C (5986 F). In addition, application of Santyl (collagenase topical ointment) to wound once a day was prescribed. Collagenase Santyl Ointment is contraindicated in patients who have shown local or systemic hypersensitivity to collagenase. Contraindications. Contraindications. 6 ADVERSE REACTIONS . Second degree burns generally leave a scar. Precautions. Side Effects. Each micelle has a hydrophilic outer surface that softens and loosens wound debris, and a hydrophobic inner core that traps debris. Indications: Collagenase SANTYL Ointment (SANTYL) is indicated for debriding chronic dermal ulcers and severely burned areas. burn/wound care surgeon podiatrist burn/wound care facility other (specify): _____ 3. Documentation that Santyl is being used for wound debridement AND 3. The optimal pH range of collagenase is 6 to 8. Short Wave Diathermy (SWD): Indication, Contra-indication & Dangers. Autolytic Debridement: This type of debridement is indicated where manageable amounts of necrotic tissue are present, and there is no infection. Frequency: 5x per week. Contraindications or hypersensitivity to the use of the study medications or their components; Therapy with another investigational agent within thirty (30) days of Visit 1. Select collagenase (santyl), and acetic vinegar drug in the Wound Care Products and provide the following: 1. Do not use with commercial wound cleansers. All information, including the Prescribing Information for Collagenase SANTYL Ointment, abides by the laws, regulatory requirements, and medical practices for Canada only and may not be appropriate for use outside of Canada. Contraindications. Collagenase Santyl Ointment is available in the following sizes: 30 g tube NDC 50484-010-30. The micelles link to form a matrix that continually expands and contracts. Collagenase clostridium histolyticum is a collagenase enzyme used to promote debridement of necrotic tissue in burns and skin ulcers as well as to treat Dupuytren's contracture and Peyronie's disease. In the last 15 years, more advanced hypochlorous acid (HOCl) solutions, based on electrochemistry, have emerged as safe and viable wound-cleansing agents and infection treatment adjunct therapies. Santyl (collagenase) is a topical medication used for removing damaged or burned skin to allow for wound healing and growth of healthy skin. This product helps to soften and loosen earwax, making it easier to Inform providers about new requirements for prior authorization of Santyl Ointment (collagenase). How to apply. Use caution in patients with burns. Chronic wounds, painful wounds, and skin conditions such as leg ulcers, radiation therapy damage, skin tears, burns and scalds. Hydrofera Blue provides wound care professionals a suite of multifaceted, intuitive, and cost-effective products for a range of wound care needs. Contraindications: SANTYL is contraindicated in patients who have shown local or systemic hypersensitivity to collagenase. CONTRAINDICATIONS. This study is designed to compare SANTYL versus hydrogel (SoloSite) in the treatment of pressure ulcers for participants in a long-term care facility. Dry stable heel eschar. WARNINGS. Bandages will be used to keep the burn covered while it heals. Contraindications. Do not use with Santyl as Medication Uses | How To Use | Side Effects | Precautions | Drug Interactions | Overdose | Notes | Missed Dose | Storage. Providing a path for the migration of key healing factors. Efficacy will be adversely affected by detergents, denaturants, extreme pH & certain heavy metal ions. The information on this site is intended for customers, patients, and healthcare professionals in Canada only. Higher or lower pH conditions will decrease the enzymes activity and appropriate precautions should be taken. Is ideal for pain sensitive patients, as PluroGel reduces pain (and improves compliance) of dressing changes. Applies to collagenase topical: topical application ointment. Be careful to apply the ointment only within the affected area. Cost effective, but requires prescription. Types of Debridement. Medication Uses | How To Use | Side Effects | Precautions | Drug Interactions | Overdose | Notes | Missed Dose | Storage. Short Wave Diathermy (SWD) is the therapeutic application of the high frequency of the alternating current that produces electromagnetic energy and provides deep heating in joints and soft tissues. Small doses salivary and bronchial secretions and sweating; intermediate doses dilate the pupil, inhibit accommodation, heart rate (vagolytic action); large doses GI and GU motility, further in dose gastric acid secretion. Dont use collagen dressings in the following circumstances: third-degree burns patient sensitivity to bovine (cattle), porcine (swine), or avian (bird) products wounds covered in dry eschar. Do not moisten dressing prior to placing in wound bed. 6.1 Clinical Trials Experience 7 DRUG INTERACTIONS 7.1 Monoamine Oxidase (MAO) Inhibitors 7.2 Drugs that Increase Blood Pressure and/or Heart Rate . Ischemic wounds with dry gangrene. Therapy Information: Modality: Megapulse II Shortwave Diathermy. Other Therapy Services Provided: Postural training and education. PRECAUTIONS CONTRAINDICATIONS. It works by helping to break up and remove dead skin and tissue. Debridement can be conducted via surgical, autolytic, enzymatic, biologic, or mechanical methods. BRAND NAME(S): Santyl. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. Effective Date: June 1, 2022 Clinical Criteria, Step Therapy, and Quantity Limits 5.2 Psychiatric Symptoms . This condition causes diarrhea and stomach/abdominal pain. Collagenase Santyl Ointment is indicated for debriding chronic dermal ulcers 2, 3, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18 and severely burned areas.3, 4, 5, 7, 16, 19, 20, 21 CONTRAINDICATIONS Collagenase Santyl Ointment is contraindicated in patients who have shown local or systemic hypersensitivity to collagenase. Ask a doctor in cases of deep or puncture wounds, serious burns, or animal bites. Common side effects of Santyl include: pain or a burning feeling at the affected area, or ; temporary redness or irritation in the skin around the affected area. Santyl is supplied in single-use glass vials containing 0.9 mg of Santyl clostridium histolyticum as a sterile, lyophilized powder for reconstitution.